尘肺病患者因矿物粉尘导致的闭塞性中央支气管炎
Obliterative central bronchitis due to mineral dust in patients with pneumoconiosis.
作者信息
Kampalath B N, McMahon J T, Cohen A, Tomashefski J F, Kleinerman J
机构信息
Department of Pathology, Case Western Reserve University, School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109-1998, USA.
出版信息
Arch Pathol Lab Med. 1998 Jan;122(1):56-62.
OBJECTIVE
We studied at autopsy a distinctive obliterative bronchitis in three persons with pneumoconiosis and hilar node fibrosis.
METHODS
Lungs were evaluated macroscopically, microscopically, and with energy-dispersive spectroscopy.
RESULTS
Chest roentgenogram demonstrated right middle lobe syndrome in one patient; bronchostenosis was seen at bronchoscopy in another. The stenotic sites were in perihilar bronchi and showed an upper lobe predominance. Fibrosis with silicotic nodules involved the bronchus, peribronchial tissue, and adjacent lymph nodes. Simple coalworkers' pneumoconiosis was observed in two patients; the third had complicated, mixed dust fibrosis.
CONCLUSION
Obliterative bronchitis represents an unusual fibrotic response to free crystalline silica. The process may occur simultaneously in the adjacent lymph node and the bronchial wall; however, it need not be associated with complicated pneumoconiosis. Clinically, obliterative bronchitis may masquerade as bronchogenic carcinoma.
目的
我们对三名患有尘肺病和肺门淋巴结纤维化的患者尸体进行解剖，研究一种独特的闭塞性支气管炎。
方法
对肺部进行宏观、微观评估以及能谱分析。
结果
胸部X线片显示一名患者有右中叶综合征；另一名患者在支气管镜检查时可见支气管狭窄。狭窄部位位于肺门周围支气管，以上叶为主。伴有矽结节的纤维化累及支气管、支气管周围组织及相邻淋巴结。两名患者观察到单纯性煤工尘肺；第三名患者为复杂的混合性粉尘纤维化。
结论
闭塞性支气管炎是对游离结晶二氧化硅的一种不寻常的纤维化反应。该过程可能同时发生在相邻淋巴结和支气管壁；然而，它不一定与复杂的尘肺病相关。临床上，闭塞性支气管炎可能伪装成支气管源性癌。
Zotero 插件