van Oostayen J A, Wasser M N, Griffioen G, van Hogezand R A, Lamers C B, de Roos A
Department of Diagnostic Radiology, Leiden University Medical Center, The Netherlands.
Am J Gastroenterol. 1998 Jan;93(1):88-91. doi: 10.1111/j.1572-0241.1998.088_c.x.
To assess the value of measurements of superior mesenteric artery flow using Doppler ultrasound for detecting disease activity in patients with proven or suspected Crohn's disease.
Superior mesenteric artery flow was measured prospectively in 31 patients with known or suspected small-bowel disease. Sixteen patients were known to suffer from Crohn's disease and were suspected of having active disease. Fifteen patients had abdominal complaints without a specific diagnosis. Enteroclysis was used as the standard of reference to detect Crohn's disease, to define the location of small-bowel Crohn's disease, and to assess disease activity by demonstrating cobblestoning. Disease activity was further substantiated by clinical signs, laboratory values, and clinical follow-up.
Ten patients with active disease on enteroclysis made up group 1. Group 2 comprised nine patients known to have Crohn's disease but without active disease (inactive small-bowel disease). The remaining 12 patients made up group 3. In group 1, the flow volume values were significantly higher than those in group 2 and group 3: 738 +/- 411 (mean +/- SD) versus 364 +/- 101 and 300 +/- 91, respectively (p < 0.05).
Whereas the initial diagnosis of small-bowel involvement in Crohn's disease may rely on enteroclysis, Doppler measurements of superior mesenteric artery flow are useful to monitor the activity of Crohn's disease.
评估使用多普勒超声测量肠系膜上动脉血流对于检测已确诊或疑似克罗恩病患者疾病活动度的价值。
前瞻性地测量了31例已知或疑似小肠疾病患者的肠系膜上动脉血流。16例患者已知患有克罗恩病且怀疑有疾病活动。15例患者有腹部不适但未明确诊断。小肠灌肠造影被用作检测克罗恩病、确定小肠克罗恩病位置以及通过显示鹅卵石样改变评估疾病活动度的参考标准。通过临床体征、实验室检查值和临床随访进一步证实疾病活动度。
小肠灌肠造影显示有10例疾病活动的患者组成第1组。第2组包括9例已知患有克罗恩病但无疾病活动（小肠疾病静止期）的患者。其余12例患者组成第3组。在第1组中，血流量值显著高于第2组和第3组：分别为738±411（均值±标准差），而第2组和第3组分别为364±101和300±91（p<0.05）。
虽然克罗恩病小肠受累的初步诊断可能依赖于小肠灌肠造影，但多普勒测量肠系膜上动脉血流对于监测克罗恩病的活动度是有用的。
