Goda Y, Stevens C F
Molecular Neurobiology Laboratory and Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1283-8. doi: 10.1073/pnas.95.3.1283.
We have estimated, for hippocampal neurons in culture, the size of the autaptic readily releasable pool before and after stimulation of the sort that produces culture long term depression (LTD). This stimulation protocol causes a decrease in the pool size that is proportional to the depression of synaptic currents. To determine if depression in this system is synapse specific rather than general, we have also monitored synaptic transmission between pairs of cultured hippocampal neurons that are autaptically and reciprocally interconnected. We find that the change in synaptic strength is restricted to the synapses on the target neuron that were active during LTD induction. When viewed from the perspective of the presynaptic neuron, however, synapse specificity is partial rather than complete: synapses active during induction that were not on the target neuron were partially depressed.
我们已经估算了培养的海马神经元中，产生培养物长期抑制（LTD）的那种刺激前后自突触易释放池的大小。这种刺激方案会导致池大小的减小，其与突触电流的抑制成比例。为了确定该系统中的抑制是突触特异性的而非一般性的，我们还监测了自突触且相互连接的成对培养海马神经元之间的突触传递。我们发现，突触强度的变化仅限于LTD诱导期间活跃的靶神经元上的突触。然而，从突触前神经元的角度来看，突触特异性是部分的而非完全的：诱导期间活跃但不在靶神经元上的突触会受到部分抑制。
