苯巴比妥对Ahr基因敲除小鼠肝脏CYP1A1和CYP1A2的影响。
Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse.
作者信息
Zaher H, Yang T J, Gelboin H V, Fernandez-Salguero P, Gonzalez F J
机构信息
Laboratory of Metabolism, National Cancer Institute, Bethesda, MD 20892, USA.
出版信息
Biochem Pharmacol. 1998 Jan 15;55(2):235-8. doi: 10.1016/s0006-2952(97)00476-0.
Studies have suggested that phenobarbital (PB) induces members of the CYP1A subfamily by both transcriptional and post-transcriptional mechanisms. Using the Ahr -/- mice, we examined the induction of CYP1A1 and CYP1A2 by PB. CYP1A2 mRNA and protein were induced by PB in the null mice, suggesting that CYP1A2 is regulated by PB by a mechanism independent of the aryl hydrocarbon receptor (AHR). In contrast, the regulation of CYP1A1 is highly dependent on the AHR.
研究表明，苯巴比妥（PB）通过转录和转录后机制诱导CYP1A亚家族成员。我们使用Ahr基因敲除小鼠研究了PB对CYP1A1和CYP1A2的诱导作用。在基因敲除小鼠中，PB可诱导CYP1A2的mRNA和蛋白质表达，这表明CYP1A2受PB调控的机制独立于芳烃受体（AHR）。相比之下，CYP1A1的调控高度依赖于AHR。
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