Rheumatic manifestations of infectious diseases in children.

Infectious diseases continue to elicit worldwide attention. Many of these diseases have rheumatic manifestations as an incidental or principal feature. Because this is particularly true in children, rheumatic manifestations of infectious diseases in this population continue to be an area of great importance to rheumatologists. A variety of bacteria, viruses, fungi, and parasitic organisms can give rise to infectious diseases with rheumatic manifestations. A high index of clinical suspicion is frequently necessary for an accurate diagnosis. Prompt diagnosis and early and appropriate therapeutic intervention are usually required for a successful, and frequently curative, outcome. Over the past year, studies have addressed the pathogenetic mechanisms and clinical spectrum of the rheumatic manifestations of infectious diseases in children. There has been particular emphasis on septic arthritis, osteomyelitis, sickle-cell disease, and hepatitis C viral infection. There remains the daunting and unfortunate possibility of large numbers of children developing HIV-associated arthritis.