Vanherweghem J L, Ducobu J, d'Hollander A, Toussaint C
Pflugers Arch. 1976 May 6;363(1):75-80. doi: 10.1007/BF00587405.
The effects of acute hypercalcemia on hemodynamics and on water and sodium excretion were studied on the blood-perfused isolated dog kidney. This model advantageously eliminates various factors which modify medullary osmolality and intrarenal hemodynamics, as well as collecting duct permeability. Calcium ion directly inhibits sodium reabsorption in the proximal tubule and in the ascending limb of Henle's loop, leading to increased sodium excretion rate and to decreased free water generation. The vasoconstrictive action of calcium, leading to decreased glomerular filtration rate, may mitigate the strong natriuretic effect of this ion.
在血液灌注的离体犬肾模型上，研究了急性高钙血症对血流动力学以及水和钠排泄的影响。该模型有利地消除了各种改变髓质渗透压、肾内血流动力学以及集合管通透性的因素。钙离子直接抑制近端小管和亨氏袢升支对钠的重吸收，导致钠排泄率增加和自由水生成减少。钙的血管收缩作用导致肾小球滤过率降低，这可能会减轻该离子强大的利钠作用。
