Shakhmatova E I, Natochin Iu V, Pinegin L E, Sokolova M M, Tibekina L M
Fiziol Zh SSSR Im I M Sechenova. 1978 Mar;64(3):315-22.
Simultaneous suppression of reabsorption in the proximal tubule with the aid of polyethylenglucole 400 (PEG) and in ascending part of Henle's loop with furosemide increased diuresis by 121 times and natri-uresis by 242 times on the average. The increase was based on changes in the tubule reabsorption and secretion. The changes of sodium and calcium excretion as well as excretion of potassium and magnesium were parallel. Excretion of sodium and calcium was lesser than the diuresis while that of magnesium and potassium exceeded it. Furosemide reduced the reabsorption of osmotically free water.
借助聚乙二醇400(PEG)同时抑制近端小管的重吸收以及用呋塞米抑制亨氏袢升支的重吸收,平均使利尿增加了121倍,利钠增加了242倍。这种增加是基于肾小管重吸收和分泌的变化。钠和钙排泄的变化以及钾和镁的排泄变化是平行的。钠和钙的排泄量低于尿量,而镁和钾的排泄量超过尿量。呋塞米减少了渗透自由水的重吸收。