Tsambaos D, Nikiforidis G, Zografakis C, Mantagos S, Malamitsi-Puchner A, Georgiou S, Monastirli A, Pasmatzi E
Department of Dermatology, University of Patras, Greece.
Skin Pharmacol. 1997;10(5-6):303-8. doi: 10.1159/000211519.
Using a new computerized methodological procedure a separate analysis and a quantitative determination of the viscous and elastic parameters of the scalp hair shaft were performed in 37 neonates of both sexes with a gestational age of 28-29 weeks (n = 16) and 39-40 weeks (n = 21), respectively. A statistically significant (p < 0.001) decrease in the values of modulus of elasticity (E alpha) was found in the hair shaft of premature neonates, as compared to the full-term ones, whereas the values of post yield slope (E beta) and of SDIS/SSTOR (viscous parameter) did not significantly differ in the two groups. The decrease in modulus of elasticity in the hair shaft of premature neonates may be interpreted in terms of an insufficient number of disulphide bonds between the alpha-helical keratin units of the hair cortex or of a disordered arrangement of microfibrils within the matrix. Further studies are now warranted to determine the pattern of mechanical parameters of the scalp hair shaft in large numbers of newborn infants of different gestational ages and to answer the question as to whether this pattern might be useful in the accurate postnatal assessment of fetal maturation.
采用一种新的计算机化方法程序，分别对37名胎龄为28 - 29周（n = 16）和39 - 40周（n = 21）的男女新生儿的头皮毛干的粘性和弹性参数进行了单独分析和定量测定。与足月儿相比，早产儿毛干的弹性模量（Eα）值有统计学显著下降（p < 0.001），而两组的屈服后斜率（Eβ）和SDIS/SSTOR（粘性参数）值无显著差异。早产儿毛干弹性模量的下降可能是由于毛皮质的α - 螺旋角蛋白单元之间二硫键数量不足，或者是基质内微原纤维排列紊乱所致。现在有必要进行进一步研究，以确定大量不同胎龄新生儿头皮毛干的力学参数模式，并回答这种模式是否有助于准确进行胎儿成熟度的产后评估这一问题。
