Buchbinder B R, Cosgrove G R
Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Magn Reson Imaging Clin N Am. 1998 Feb;6(1):67-93.
Principles and clinical applications of functional MR imaging activation studies are presented. The physical and physiologic basis for cerebral blood volume-, cerebral blood flow-, and oxygenation-based functional MR imaging techniques are reviewed. The methodology of blood oxygen level dependent (BOLD) functional MR imaging is emphasized. Applications to presurgical mapping of sensorimotor and language function in patients with vascular malformations, tumors, and other lesions near critical cortical areas are illustrated. Important new applications to neuropsychiatric diseases are highlighted.
本文介绍了功能磁共振成像激活研究的原理及临床应用。回顾了基于脑血容量、脑血流量和氧合的功能磁共振成像技术的物理和生理基础。重点强调了血氧水平依赖（BOLD）功能磁共振成像的方法。阐述了其在血管畸形、肿瘤及其他临近关键皮质区域病变患者的感觉运动和语言功能术前定位中的应用。突出了其在神经精神疾病方面的重要新应用。
