3-甲基胆蒽对新生大鼠溴磺酞钠和伊红胆汁排泄的影响。

Effect of 3-methylcholanthrene on the biliary excretion of bromsulphthalein and eosine in newborn rats.

作者信息

Kleeberg U, Fishcer E, Gregus Z, Klinger W, Varga F

出版信息

Acta Physiol Acad Sci Hung. 1979;53(3):363-7.

Abstract

The biliary excretion rates of bromsulphthalein (BSP), bromsulphthalein-glutathione conjugate (BSP-GSH) and eosine have been studied in 3-methylcholanthrene (3-MC)-pretreated (100 mg/kg i.p.) and control rats aged 10 days. Liver weight was invariably increased after 3-MC treatment, associated with enhanced biliary excretion of total BSP. The increase in the biliary excretion of total BSP was due solely to the increased excretion of BSP-GSH. Following 3-MC pretreatment, BSP-GSH and eosine appeared in the bile in the same amount as in the control rats after i.v. administration of BSP-GSH and eosine. Pretreatment with 3-MC increased the ratio of BSP-GSH to BSP in the liver and bile. Our results suggest that the increased biliary excretion of total BSP following 3-MC treatment was due to an enhanced conjugation of BSP with GSH.

摘要

在10日龄经3-甲基胆蒽（3-MC）预处理（腹腔注射100mg/kg）的大鼠和对照大鼠中，研究了溴磺酞钠（BSP）、溴磺酞钠-谷胱甘肽共轭物（BSP-GSH）和伊红的胆汁排泄率。3-MC处理后肝脏重量总是增加，这与总BSP胆汁排泄增强有关。总BSP胆汁排泄增加完全是由于BSP-GSH排泄增加。3-MC预处理后，静脉注射BSP-GSH和伊红后，胆汁中出现的BSP-GSH和伊红量与对照大鼠相同。3-MC预处理增加了肝脏和胆汁中BSP-GSH与BSP的比例。我们的结果表明，3-MC处理后总BSP胆汁排泄增加是由于BSP与GSH的共轭作用增强。