Gregus Z, Fischer E, Varga F
Acta Med Acad Sci Hung. 1979;36(2):197-202.
The maximum biliary excretion rate (Tm) of some nonmetabolized organic anions was investigated in anaesthetized male rats and was found to increase in the following order: indocyanine green (ICG), rose bengal (RB), bromsulphthalein (BSP; its conjugation with glutathione was prevented by diethyl maleate), bromcresol green (BCG), eosine (E), BSP-glutathione conjugate (BSP-GSH), iodoxamic acid (IA) and amaranth (A). The accumulation of ICG, RB, BSP and BCG in liver was relatively high, whereas E, BSP-GSH,IA and A were taken up by the liver in a lower concentration. ICG, RB, BSP and BCG decreased the biliary flow, however, E, BSP-GSH, IA and A stimulated it. ICG, RB and BSP had a strong, BCG and E a moderate, inhibitory effect on hepatic mitochondrial respiration stimulated by ADP, DNP and glutamate-malate, whereas BSP-GSH, IA and A had no effect on this process. Our results suggest that the depressing effect of cholephilic organic anions on bile production and their low biliary excretion rates are connected with their inhibitory effects on mitochondrial respiration.
在麻醉的雄性大鼠中研究了一些非代谢有机阴离子的最大胆汁排泄率（Tm），发现其按以下顺序增加：吲哚菁绿（ICG）、孟加拉玫瑰红（RB）、磺溴酞（BSP；马来酸二乙酯可阻止其与谷胱甘肽结合）、溴甲酚绿（BCG）、曙红（E）、BSP-谷胱甘肽共轭物（BSP-GSH）、碘氧酰胺酸（IA）和苋菜红（A）。ICG、RB、BSP和BCG在肝脏中的蓄积相对较高，而E、BSP-GSH、IA和A被肝脏以较低浓度摄取。ICG、RB、BSP和BCG降低胆汁流量，然而，E、BSP-GSH、IA和A刺激胆汁流量。ICG、RB和BSP对由ADP、DNP和谷氨酸-苹果酸刺激的肝线粒体呼吸有强烈抑制作用，BCG和E有中度抑制作用，而BSP-GSH、IA和A对该过程无影响。我们的结果表明，亲胆有机阴离子对胆汁生成的抑制作用及其低胆汁排泄率与它们对线粒体呼吸的抑制作用有关。
