Martínez de Pancorbo C, Carballo F, Horcajo P, Aldeguer M, de la Villa I, Nieto E, Gaspar M J, de la Morena J
Department of Internal Medicine, University General Hospital of Guadalajara, Madrid, Spain.
J Clin Epidemiol. 1997 Dec;50(12):1347-55. doi: 10.1016/s0895-4356(97)00198-4.
We conducted a cross-sectional survey to determine the prevalence of gallstone disease (gallstone or cholecystectomy) in a random sample of the adult population of Guadalajara, Spain. The sample stratified by age and sex was drawn from the municipal census. Stratum sample sizes were proportional to population sizes and to the expected prevalence rates calculated through a meta-analysis of the European literature. The screening protocol included a gallbladder ultrasonography, a questionnaire on personal and family history, a physical examination, and a blood sample for biochemical determinations. The response rate was 61.2%. The overall prevalence of gallstone disease was 9.7% (95% CI, 7.3-12.0). Prevalence was higher (but not statistically significant) in women (11.5%; 95% CI, 8.2-14.7) than in men (7.8%; 95% CI, 4.6-11.1). After controlling for confounding by multiple logistic regression, increasing age, body mass index, dyspeptic symptoms, smoking habit, and use of hypolipidemic drugs were positively associated with gallstone disease. Total serum cholesterol and alcohol consumption were negatively associated.
我们进行了一项横断面调查，以确定西班牙瓜达拉哈拉成年人群随机样本中胆结石疾病（胆结石或胆囊切除术）的患病率。按年龄和性别分层的样本取自市政人口普查。各层样本量与人口规模以及通过对欧洲文献的荟萃分析计算出的预期患病率成比例。筛查方案包括胆囊超声检查、个人和家族病史问卷、体格检查以及用于生化测定的血样。应答率为61.2%。胆结石疾病的总体患病率为9.7%（95%可信区间，7.3 - 12.0）。女性患病率较高（但无统计学显著性），为11.5%（95%可信区间，8.2 - 14.7），男性为7.8%（95%可信区间，4.6 - 11.1）。在通过多因素逻辑回归控制混杂因素后，年龄增加、体重指数、消化不良症状、吸烟习惯以及使用降血脂药物与胆结石疾病呈正相关。血清总胆固醇和饮酒量与胆结石疾病呈负相关。
