Santamore W P, Dell'Italia L J
Jewish Hospital Cardiothoracic Surgical Research Institute, Division of Thoracic and Cardiovascular Surgery, University of Louisville, KY 40292, USA.
Prog Cardiovasc Dis. 1998 Jan-Feb;40(4):289-308. doi: 10.1016/s0033-0620(98)80049-2.
This article reviews diastolic and systolic ventricular interaction, and clinical pathophysiological conditions involving ventricular interaction. Diastolic ventricular interdependence is present on a moment-to-moment, beat-to-beat basis, and the interactions are large enough to be of physiological and pathophysiological importance. Although always present, ventricular interdependence is most apparent with sudden postural and respiratory changes in ventricular volume. Left ventricular function significantly affects right ventricular systolic function. Experimental studies have shown that about 20% to 40% of the right ventricular systolic pressure and volume outflow result from left ventricular contraction. This dependency of the right ventricle on the left ventricle helps to explain the right ventricular response to volume overload, pressure overload, and myocardial ischemia. The septum and its position are not the sole mechanism for ventricular interdependence. Ventricular interdependence causes overall ventricular deformation, and is probably best explained by the balance of forces at the interventricular sulcus, the material properties, and cardiac dimensions.
本文综述了舒张期和收缩期心室相互作用，以及涉及心室相互作用的临床病理生理状况。舒张期心室相互依存关系每时每刻、逐搏存在，且这种相互作用足够大，具有生理和病理生理重要性。尽管心室相互依存关系始终存在，但在心室容量突然发生姿势和呼吸变化时最为明显。左心室功能显著影响右心室收缩功能。实验研究表明，右心室收缩压和容积流出量的约20%至40%源于左心室收缩。右心室对左心室的这种依赖性有助于解释右心室对容量超负荷、压力超负荷和心肌缺血的反应。室间隔及其位置并非心室相互依存的唯一机制。心室相互依存导致整体心室变形，可能最好用室间沟处的力平衡、材料特性和心脏尺寸来解释。
