氯乙基亚硝脲抗肿瘤活性的化学基础。 - Suppr

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A chemical basis for the antitumor activity of chloroethylnitrosoureas.

作者信息

Colvin M, Brundrett R B, Cowens W, Jardine I, Ludlum D B

出版信息

Biochem Pharmacol. 1976 Mar 15;25(6):695-9. doi: 10.1016/0006-2952(76)90246-x.

DOI:10.1016/0006-2952(76)90246-x

PMID:945062

Abstract

摘要

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A chemical basis for the antitumor activity of chloroethylnitrosoureas.氯乙基亚硝脲抗肿瘤活性的化学基础。

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Comparison of biochemical and biological effects of four nitrosoureas with differing carbamoylating activities.四种具有不同氨甲酰化活性的亚硝基脲的生化和生物学效应比较。

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A structure-activity analysis of chemical and biological parameters of chloroethylnitrosoureas in mice.

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DNA damage and repair in mouse leukemia L1210 cells treated with nitrogen mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas.用氮芥、1,3-双（2-氯乙基）-1-亚硝基脲及其他亚硝基脲处理的小鼠白血病L1210细胞中的DNA损伤与修复

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[Antitumor activity of a new nitrosourea, MCNU, on a cellular morphological basis evaluated by a new in vitro antitumor sensitivity assay].

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Effects of carbamoylation on cell survival and DNA repair in normal human embryo cells (IMR-90) treated with various 1-(2-chloroethyl)-1-nitrosoureas.氨甲酰化对用各种1-(2-氯乙基)-1-亚硝基脲处理的正常人胚胎细胞（IMR-90）的细胞存活和DNA修复的影响。

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Reactions of 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in aqueous solution.1,3-双（2-氯乙基）-1-亚硝基脲和1-（2-氯乙基）-3-环己基-1-亚硝基脲在水溶液中的反应

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DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells.卤代乙基亚硝基脲在L1210细胞中导致的DNA-蛋白质交联和DNA链间交联

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Modifications of DNA by different haloethylnitrosoureas.不同卤代乙基亚硝基脲对DNA的修饰作用。

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