Cutrer F M, Sorensen A G, Weisskoff R M, Ostergaard L, Sanchez del Rio M, Lee E J, Rosen B R, Moskowitz M A
Stroke and Neurovascular Regulation, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA.
Ann Neurol. 1998 Jan;43(1):25-31. doi: 10.1002/ana.410430108.
Perfusion- and diffusion-weighted magnetic resonance imaging was performed during spontaneous visual auras in four migraineurs. Alterations in relative cerebral blood flow (16-53% decrease), cerebral blood volume (6-33% decrease), and tissue mean transit time (10-54% increase) were observed in the gray matter of occipital cortex contralateral to the affected visual hemifield. No changes in the apparent diffusion coefficient were observed either while the patients were symptomatic or after resolution of the visual symptoms but before the onset of headache. Functional magnetic resonance imaging can be a useful noninvasive tool to study hemodynamic changes during spontaneous attacks of migraine with aura.
对4名偏头痛患者在自发视觉先兆期间进行了灌注加权和扩散加权磁共振成像。在受影响的视觉半视野对侧枕叶皮质的灰质中观察到相对脑血流量（减少16 - 53%）、脑血容量（减少6 - 33%）和组织平均通过时间（增加10 - 54%）的改变。在患者出现症状时或视觉症状消退后但头痛发作前，表观扩散系数均未观察到变化。功能磁共振成像可能是研究伴有先兆偏头痛自发发作期间血流动力学变化的一种有用的非侵入性工具。
