Montgomery J A, Struck R F
Cancer Treat Rep. 1976 Apr;60(4):381-93.
The synthesis of approximately 80 cyclic or acyclic analogs of cyclophosphamide, isophosphamide, triphosphamide, and phosphoramide mustard is outlined briefly. All of the analogs contain at least one 2-chloroethyl or bis(2-chloroethyl)-amino group bound to phosphorus. Representatives of some of the various classes of analogs were evaluated against murine L1210 leukemia in vivo. Some of the cyclic oxidized derivatives and a phosphorodiamidic chloride yielded long-term survivors. 4-Peroxycyclophosphamide was also active against ic implanted L1210 leukemia and against two other murine tumors, Lewis lung carcinoma and C3H mammary tumor.
简要概述了约80种环磷酰胺、异环磷酰胺、三磷酰胺和磷酰胺氮芥的环状或非环状类似物的合成。所有类似物均含有至少一个与磷相连的2-氯乙基或双（2-氯乙基）氨基。对一些不同类别的类似物代表进行了体内抗小鼠L1210白血病评估。一些环状氧化衍生物和一种磷二酰胺氯化物产生了长期存活者。4-过氧环磷酰胺对皮下植入的L1210白血病以及另外两种小鼠肿瘤，即Lewis肺癌和C3H乳腺癌也有活性。
