Waki S, Kinoshita Y, Fukui H, Maekawa T, Okada A, Matsushima Y, Hassan S, Sakatani T, Kawanami C, Kishi K, Chiba T
Division of Gerontology, Kobe University School of Medicine, Japan.
J Clin Gastroenterol. 1997 Dec;25(4):592-4. doi: 10.1097/00004836-199712000-00008.
During the long-term administration of nonsteroidal anti-inflammatory drugs (NSAIDs), approximately 3% of patients have gastric ulcers develop in each year. Although much is known about the endoscopic characteristics of NSAID-induced gastric ulcers in patients with rheumatoid arthritis (RA), it is not clear where in the stomach NSAIDs induce ulcers in patients without RA. We looked at that question. During the 1-year study period, 29 patients with gastric ulcer, who had been taking NSAIDs regularly for more than 4 weeks mainly for osteoarthritis, were identified. Seventy-five patients with gastric ulcers who had not taken NSAID also were found. The sites of gastric ulcers of these two groups were quite different. The NSAID-induced ulcers mainly were found in the gastric antrum, whereas the majority of NSAID-unrelated ulcers were in the gastric corpus. We conclude that NSAID-induced ulcers in non-RA patients mainly are formed in the gastric antrum.
在长期服用非甾体抗炎药（NSAIDs）期间，每年约有3%的患者会发生胃溃疡。虽然对于类风湿关节炎（RA）患者中NSAIDs所致胃溃疡的内镜特征已有很多了解，但对于无RA的患者，NSAIDs在胃的哪个部位诱发溃疡尚不清楚。我们研究了这个问题。在为期1年的研究期间，确定了29例主要因骨关节炎规律服用NSAIDs超过4周的胃溃疡患者。还发现了75例未服用NSAIDs的胃溃疡患者。这两组胃溃疡的部位有很大差异。NSAIDs诱发的溃疡主要位于胃窦，而大多数与NSAIDs无关的溃疡位于胃体。我们得出结论，非RA患者中NSAIDs诱发的溃疡主要在胃窦形成。
