Hagedorn H W, Schulz R
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztlichen Fakultät, Universität München.
Berl Munch Tierarztl Wochenschr. 1997 Dec;110(11-12):456-60.
Statistical analysis of normally occurring cortisol levels in serum and urine of horses served to recommend thresholds for this corticosteroid in these body fluids, as application of exogenous cortisol as well as ACTH may elevate the cortisol concentrations above the proposed threshold. The present study contributes to the general issue of how to establish thresholds for trotting horses upon sportive examination. 100 randomly selected post competition serum and urine samples, respectively, were submitted to cortisol analysis by means of HPLC. Concentrations of the endogenous corticosteroid in serum and urine followed a log-normal distribution with mean values of 61 and 49 ng/ml, respectively. The probability was 1: 100,000 to exceed concentration limits of 230 (serum) and 394 ng/ml (urine). Designation of thresholds for cortisol has proven problematic and is discussed here.
对马血清和尿液中正常出现的皮质醇水平进行统计分析，有助于确定这些体液中该皮质类固醇的阈值，因为外源性皮质醇以及促肾上腺皮质激素的应用可能会使皮质醇浓度升高至建议阈值以上。本研究有助于解决在运动检查时如何为快步马确定阈值这一普遍问题。分别随机选取100份赛后血清和尿液样本，通过高效液相色谱法进行皮质醇分析。血清和尿液中内源性皮质类固醇的浓度呈对数正态分布，平均值分别为61和49纳克/毫升。超过230纳克/毫升（血清）和394纳克/毫升（尿液）浓度限值的概率为十万分之一。事实证明，确定皮质醇的阈值存在问题，本文对此进行了讨论。
