Vaugeois J M, Passera G, Zuccaro F, Costentin J
UPRESA CNRS 6036, Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculté de Médecine et Pharmacie de Rouen, Saint-Etienne du Rouvray, France.
Psychopharmacology (Berl). 1997 Dec;134(4):387-91. doi: 10.1007/s002130050475.
The tail suspension test is a behavioural primary screen for detecting potential antidepressant drugs. In this test, a reduction of duration of immobility after treatment with imipramine is obtained in mice of the NMRI strain but not of the CD1 strain. The present experiments evidence important differences between individuals of the latter strain in both the amount of immobility observed in naive mice and the effects of three antidepressants. The reproducibility of the tail suspension-induced behavioural despair was high in individual CD1 male mice and allowed a preselection of spontaneous high and low immobility scorers. Only the high immobility scorers were responsive to imipramine (30 mg/kg), desipramine (30 mg/kg) and paroxetine (10 mg/kg). The percentage of spontaneous high immobility scorers was higher in NMRI (50%) than in CD1 (20%) mice, justifying the use of the former strain for screening potential antidepressants. However, controlling for individual differences in the spontaneous performance in this animal model of depression may provide a useful tool to study behavioural, neurochemical and neuroendocrine correlates of antidepressant action.
悬尾试验是一种用于检测潜在抗抑郁药物的行为学初步筛选方法。在该试验中，用丙咪嗪治疗后，NMRI品系小鼠的不动时间缩短，但CD1品系小鼠则不然。本实验证明，后一品系的个体在未处理小鼠的不动时间以及三种抗抑郁药的效果方面存在重要差异。在个体CD1雄性小鼠中，悬尾诱导的行为绝望具有很高的可重复性，从而能够预先筛选出不动时间自发高和低的评分者。只有不动时间高的评分者对丙咪嗪（30mg/kg）、地昔帕明（30mg/kg）和帕罗西汀（10mg/kg）有反应。NMRI小鼠（50%）中自发不动时间高的评分者百分比高于CD1小鼠（20%），这证明使用前一品系来筛选潜在抗抑郁药是合理的。然而，在这种抑郁动物模型中控制自发行为表现的个体差异，可能为研究抗抑郁作用的行为、神经化学和神经内分泌相关性提供一个有用的工具。
