Kwa H G, Cleton F, de Jong-Bakker M, Bulbrook R D, Hayward J L, Wang D Y
Int J Cancer. 1976 Apr 15;17(4):441-7. doi: 10.1002/ijc.2910170405.
The prolactin concentration has been determined in plasma from ostensibly healthy women living on the Island of Guernsey. There were 102, 42, and 41 women who had a mother, sister or maternal aunt, respectively, with breast cancer. The remaining 184 women in this study claimed to have no known family history of breast cancer and were used as a control group. The increased risk of breast cancer due to family history was not associated with a raised mean prolactin level compared to the control group. However, in the luteal phase of the menstrual cycle, daughters of breast cancer patients had significantly raised levels of prolactin at 19.00 h. There were no abnormalities in the mean plasma prolactin levels for the above groups associated with differences in age at first child, age at menarche, interval between age at menarche and first child, and body weight of post-menopausal women. (All these factors have been reported to influence breast cancer risk). It is concluded that prolactin has no obvious function in the aetiology of breast cancer. If it is involved, the mechanism by which it acts must be subtle and concerned with the homeostatic control governing nycthemeral prolactin rhythms.
已对根西岛表面健康女性的血浆催乳素浓度进行了测定。分别有102名、42名和41名女性的母亲、姐妹或姨妈患有乳腺癌。本研究中其余184名女性声称没有已知的乳腺癌家族史，用作对照组。与对照组相比，因家族史导致的乳腺癌风险增加与平均催乳素水平升高无关。然而，在月经周期的黄体期，乳腺癌患者的女儿在19:00时催乳素水平显著升高。上述各组的平均血浆催乳素水平与初产年龄、初潮年龄、初潮年龄与初产年龄之间的间隔以及绝经后女性体重的差异无关。（所有这些因素均已报道会影响乳腺癌风险）。结论是催乳素在乳腺癌病因学中没有明显作用。如果它参与其中，其作用机制必定很微妙，且与昼夜催乳素节律的稳态控制有关。
