Huang Y F, Upton R N, Gray E C, Grant C, Zheng D, Ludbrook G L
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, South Australia.
Anaesth Intensive Care. 1997 Dec;25(6):627-33. doi: 10.1177/0310057X9702500605.
The cardiovascular effects of slow (over two minutes) intravenous infusions of thiopentone 750 mg in conscious instrumented sheep breathing 100% oxygen were examined for 30 minutes following the start of the infusion. The maximum rate of rise of left ventricular pressure (an index of myocardial contractility) decreased significantly from 1 to 10 minutes, to a minimum of 45% of baseline. Heart rate increased by up to 33% above baseline from 0.5 min onwards. Both mean arterial pressure and cardiac output were decreased from between 1 and 7 min. Left ventricular minute work was transiently decreased, but left coronary blood flow and myocardial oxygen consumption showed little or no change from baseline. We conclude that in vivo, thiopentone administered at a relatively slow rate caused large reductions in myocardial contractility, and therefore cardiac reserve, in the absence of significant changes in myocardial blood flow or oxygen consumption.
在有意识的、安装了仪器的绵羊呼吸100%氧气的情况下，研究了静脉缓慢（超过两分钟）输注750毫克硫喷妥钠的心血管效应，在输注开始后的30分钟内进行观察。左心室压力的最大上升速率（心肌收缩力指标）在1至10分钟时显著下降，降至基线的45%的最低值。心率从0.5分钟起比基线最高增加33%。平均动脉压和心输出量在1至7分钟之间均下降。左心室每分钟功短暂下降，但左冠状动脉血流量和心肌氧耗与基线相比几乎没有变化。我们得出结论，在体内，以相对缓慢的速率给予硫喷妥钠会在心肌血流量或氧耗无显著变化的情况下，导致心肌收缩力大幅降低，进而使心脏储备能力下降。
