McIntosh E N
J Clin Endocrinol Metab. 1976 Jun;42(6):1192-5. doi: 10.1210/jcem-42-6-1192.
Three women with the galactorrhea-amenorrhea syndrome and elevated prolactin concentrations experienced a return of regular ovulatory menses within 37-94 days after starting pyridoxine treatment (200-600 mg/day). In each the galactorrhea ceased and serum prolactin levels were maintained in the normal range while taking pyridoxine. In two other women with prolonged secondary amenorrhea but without hyperprolactinemia or galactorrhea, pyridoxine at dosages up to 600 mg/day did not restore ovulatory menses. Pyridoxine treatment was also ineffective in decreasing profuse galactorrhea in one woman with normal prolactin levels and regular ovulatory menses. In the three women effectively treated with pyridoxine, the galactorrhea returned, serum prolactin levels increased, and the menses ceased after discontinuing pyridoxine. These results imply that pyridoxine, by decreasing the excessive secretion of prolactin, may be useful in the long-term medical management of women with hyperprolactinemia and the galactorrhea-amenorrhea syndrome.
三名患有溢乳 - 闭经综合征且催乳素浓度升高的女性，在开始服用吡哆醇（200 - 600毫克/天）后的37 - 94天内，恢复了规律的排卵性月经。在服用吡哆醇期间，每位患者的溢乳均停止，血清催乳素水平维持在正常范围内。另外两名继发性闭经时间延长但无高催乳素血症或溢乳的女性，每天服用高达600毫克的吡哆醇并不能恢复排卵性月经。吡哆醇治疗对一名催乳素水平正常且有规律排卵性月经的女性的大量溢乳也无效。在三名用吡哆醇有效治疗的女性中，停用吡哆醇后溢乳复发，血清催乳素水平升高，月经停止。这些结果表明，吡哆醇通过减少催乳素的过度分泌，可能对高催乳素血症和溢乳 - 闭经综合征女性的长期药物治疗有用。
