Zimmermann L, Antébi H, Morvan-Bourcier C, Alcindor L G
Service Pharmacie, Hôpital Joffre, Draveil.
Ann Pharm Fr. 1997;55(6):246-53.
The inhibition of lipoprotein catabolism after triton WR-1339 intravenous administration is associated with an impressive modification in the balance between plasma peroxidable substrates and antioxidants. Treated rat plasma and membrane lipids become peroxiaable when they are incubated with phenylhydrazine in standardized conditions and the production of thiobarbituric acid-reactive substances (lipoperoxidation markers) significantly increases. An accumulation of native lipoproteins which present a decreased alpha-tocopherol on triglycerid ratio and a modification in the plasmatic balance between alpha-tocopherol and ascorbate could explain these observations.
静脉注射曲通WR-1339后脂蛋白分解代谢的抑制与血浆可过氧化底物和抗氧化剂之间平衡的显著改变有关。当在标准化条件下与苯肼一起孵育时，经处理的大鼠血浆和膜脂变得可过氧化，并且硫代巴比妥酸反应性物质（脂质过氧化标志物）的产生显著增加。天然脂蛋白的积累，其甘油三酯与α-生育酚的比例降低，以及α-生育酚和抗坏血酸之间血浆平衡的改变，可以解释这些观察结果。
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