Wistar大鼠体内天然脂蛋白的抗氧化能力较弱。
Weak resistance to oxidation of native lipoproteins in Wistar rats.
作者信息
Antébi H, Zimmermann L, Malagrida L, Pecquery R, Olichon D, Giudicelli Y, Alcindor L G
机构信息
Department of Biochemistry, UFR des Saints-Pères, Paris, France.
出版信息
Ann Nutr Metab. 1993;37(2):62-7. doi: 10.1159/000177751.
We report an impressive decline in plasma lipid resistance to oxidation during Triton-WR-1339-induced hyperlipidemia in rats. This decline is associated with a modification in the balances between alpha-tocopherol and lipids and alpha-tocopherol and ascorbate. These results are consistent with a weak resistance of accumulated native lipoproteins in plasma to oxidation, during a 6-hour time course, and they suggest a misunderstood role of lipoprotein catabolic enzymes: to improve this characteristic. Conclusively, the results lead us to propound Triton-induced hyperlipidemia as an original model for studying the balance impairment between antioxidants and oxidizable substrates.
我们报道了在 Triton-WR-1339 诱导的大鼠高脂血症期间，血浆脂质抗氧化能力显著下降。这种下降与α-生育酚与脂质之间以及α-生育酚与抗坏血酸之间平衡的改变有关。这些结果与血浆中积累的天然脂蛋白在 6 小时时间进程中对氧化的弱抗性一致，并且表明脂蛋白分解代谢酶的作用被误解了：即改善这一特性。总之，这些结果使我们提出 Triton 诱导的高脂血症作为研究抗氧化剂与可氧化底物之间平衡受损的原始模型。
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