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CD8 + T细胞对结核分枝杆菌感染的保护作用需要γ干扰素的产生。

Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon.

作者信息

Tascon R E, Stavropoulos E, Lukacs K V, Colston M J

机构信息

National Institute for Medical Research, London, United Kingdom.

出版信息

Infect Immun. 1998 Feb;66(2):830-4. doi: 10.1128/IAI.66.2.830-834.1998.

DOI:10.1128/IAI.66.2.830-834.1998
PMID:9453650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC107978/
Abstract

The role of CD8 T cells in controlling Mycobacterium tuberculosis infections in mice was confirmed by comparing the levels of growth of the organism in control, major histocompatibility complex class II knockout, and athymic mice and by transferring T-cell populations into athymic mice. By using donor mice which were incapable of making gamma interferon (IFN-gamma), it was shown that IFN-gamma production was essential for CD8 cell mediation of protective immunity against M. tuberculosis.

摘要

通过比较在对照小鼠、主要组织相容性复合体II类基因敲除小鼠和无胸腺小鼠中该病原体的生长水平，并通过将T细胞群体转移到无胸腺小鼠中，证实了CD8 T细胞在控制小鼠结核分枝杆菌感染中的作用。通过使用无法产生γ干扰素（IFN-γ）的供体小鼠，研究表明IFN-γ的产生对于CD8细胞介导的抗结核分枝杆菌保护性免疫至关重要。

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本文引用的文献

1
Pillars Article: The Kinetics of Emergence and Loss of Mediator T Lymphocytes Acquired in Response to Infection with . . 1987. 138: 293-298.支柱文章：感染后获得的调节性T淋巴细胞出现和消失的动力学……1987年。138：293 - 298。
J Immunol. 2017 Aug 1;199(3):833-838.
2
Differential effects of cytolytic T cell subsets on intracellular infection.细胞溶解性T细胞亚群对细胞内感染的不同作用。
Science. 1997 Jun 13;276(5319):1684-7. doi: 10.1126/science.276.5319.1684.
3
The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms.在缺乏穿孔素或颗粒酶介导的细胞溶解机制表达的小鼠肺部中结核分枝杆菌感染的进程。
Infect Immun. 1997 Apr;65(4):1317-20. doi: 10.1128/iai.65.4.1317-1320.1997.
4
Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice.穿孔素是一种介导细胞坏死的细胞毒性分子，在小鼠体内对分枝杆菌感染的早期控制中并非必需。
Infect Immun. 1997 Jan;65(1):127-32. doi: 10.1128/iai.65.1.127-132.1997.
5
To kill or to cure: options in host defense against viral infection.杀死还是治愈：宿主抵御病毒感染的选择
Curr Opin Immunol. 1996 Aug;8(4):478-83. doi: 10.1016/s0952-7915(96)80034-3.
6
Stimulation of human peripheral blood mononuclear cells with live Mycobacterium bovis BCG activates cytolytic CD8+ T cells in vitro.用活的牛分枝杆菌卡介苗刺激人外周血单个核细胞可在体外激活细胞毒性CD8⁺ T细胞。
Immunology. 1996 Mar;87(3):339-42. doi: 10.1046/j.1365-2567.1996.512590.x.
7
Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65.在用表达分枝杆菌hsp65的肿瘤细胞接种小鼠后，对结核病具有高度保护性免疫的T细胞的特征分析。
Infect Immun. 1996 Jul;64(7):2400-7. doi: 10.1128/iai.64.7.2400-2407.1996.
8
A case for cytokines as effector molecules in the resolution of virus infection.细胞因子作为病毒感染消退中的效应分子的实例。
Immunol Today. 1993 Apr;14(4):155-7. doi: 10.1016/0167-5699(93)90277-R.
9
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.干扰素-γ基因缺失小鼠免疫细胞功能的多重缺陷
Science. 1993 Mar 19;259(5102):1739-42. doi: 10.1126/science.8456300.
10
Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen.αβ和γδ T细胞在抗细胞内细菌病原体免疫中的不同作用。
Nature. 1993 Sep 2;365(6441):53-6. doi: 10.1038/365053a0.