Menecier P, Menecier-Ossia L, Bern P
Département de Médecine Interne, Unité d'alcoologie, Centre Hospitalier les Chanaux, Mâcon.
Encephale. 1997 Sep-Oct;23(5):400-1.
The authors relate a single case of fluoxetine misuse of a 31-year-old woman, with a previous history of multi drug addiction, and who weaned of all illicit substance and alcohol intake for several months. From a medical fluoxetine prescription at a dose of 20 mg per day, the patient increased to 280 mg per day within few months. Tolerance and dependency to the substance (according to DSM IV) and withdrawal syndrome occurred following fluoxetine discontinuation. This misuse keeps on for more than one year, and no symptom of a "serotonin syndrome" has ever been found. In our understanding, this exceptional case-report seems to be the first one related either in medical literature or drug monitoring centers.
作者讲述了一例31岁女性滥用氟西汀的病例，该女性有多种药物成瘾史，且已戒除所有非法物质和酒精摄入数月。从每天20毫克的氟西汀医学处方开始，患者在几个月内将剂量增加到了每天280毫克。停用氟西汀后出现了对该物质的耐受性和依赖性（根据《精神疾病诊断与统计手册》第四版）以及戒断综合征。这种滥用持续了一年多，从未发现“血清素综合征”的症状。据我们所知，这一特殊病例报告似乎是医学文献或药物监测中心报道的首例。
