Zarow C, Victoroff J
Department of Neurology, University of Southern California, School of Medicine, Los Angeles 90033, USA.
Exp Neurol. 1998 Jan;149(1):79-86. doi: 10.1006/exnr.1997.6709.
The distribution of apolipoprotein E (ApoE) mRNA was characterized in the hippocampus of humans with Alzheimer disease (AD) and in rats with experimental lesions (unilateral ablation of the entorhinal cortex) that model selected features of AD. In both AD and the lesion model, we observed a shift in the location of astrocytes containing prevalent ApoE mRNA from the neuropil to regions with densely packed neurons. The increased abundance of ApoE mRNA in astrocytes close to neuron cell bodies could be indicative of lipid uptake in regions where neurons are degenerating or where synaptic remodeling is taking place.
在患有阿尔茨海默病（AD）的人类海马体以及具有模拟AD特定特征的实验性损伤（内嗅皮层单侧切除）的大鼠海马体中，对载脂蛋白E（ApoE）mRNA的分布进行了表征。在AD和损伤模型中，我们均观察到，含有大量ApoE mRNA的星形胶质细胞的位置从神经毡转移至神经元密集的区域。靠近神经元细胞体的星形胶质细胞中ApoE mRNA丰度增加，这可能表明在神经元发生退化或正在进行突触重塑的区域存在脂质摄取现象。
