Burks J S, Narayan O, McFarland H F, Johnson R T
Neurology. 1976 Jun;26(6 PT 1):584-8. doi: 10.1212/wnl.26.6.584.
An acute encephalopathy caused by a defective paramyxovirus infection was studied. Newcastle disease virus (ndv), given intracerebrally, caused neurologic disease and death in mice. Infected newborn mice died by the fourth day after inoculation, and abundant amounts of virus were recovered from their brains. Infected 4-week-old mice died by the eighth day, but only minimal amounts of virus, if any, were recovered. The brains of many moribund 4-week-old mice were histologically normal and contained no NDV antigen on fluorescent antibody staining. No serum antibody to NDV was detected. These features make this infection difficult to distinguish from a metabolic encephalopathy.
对由缺陷型副粘病毒感染引起的急性脑病进行了研究。脑内接种新城疫病毒（NDV）可导致小鼠出现神经疾病并死亡。接种后第4天，感染的新生小鼠死亡，其脑内可分离出大量病毒。感染的4周龄小鼠在第8天死亡，但即便能分离出病毒，数量也极少。许多濒死的4周龄小鼠的大脑在组织学上正常，荧光抗体染色未发现NDV抗原。未检测到针对NDV的血清抗体。这些特征使得这种感染难以与代谢性脑病相区分。
