Fujii T, Tanaka M, Yazaki Y, Kitabayashi H, Koizumi T, Sekiguchi M, Gomi T, Yano K, Itoh A
School of Allied Medical Sciences, Shinshu University School of Medicine.
Kaku Igaku. 1997 Nov;34(11):1005-11.
123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy was performed in 64 patients with heart and lung diseases. Distribution of MIBG in the chest was evaluated by planar images, using counts ratios of the heart to the mediastinum (H/M) and the unilateral lung to the mediastinum (Lu/M). Most of patients with heart diseases showed obvious lung uptake of MIBG. The ratios of H/M were 1.75 +/- 0.20 in the group without heart failure and 1.55 +/- 0.19 in the group with heart failure. The ratios of Lu/M in the right and left lung were 1.56 +/- 0.16 and 1.28 +/- 0.16 in the group without heart failure. And those were 1.45 +/- 0.16 and 1.19 +/- 0.15 in the group with heart failure. But 3 patients complicated with chronic pulmonary emphysema and one patient with interstitial pneumonia due to dermatomyositis showed markedly decreased lung uptake. The ratios of Lu/M in the right and left lung of these patients were 1.20, 1.17; 1.17, 1.13; 1.01, 0.97 and 1.27, 0.94, respectively. These results suggest that the lung uptake of MIBG may reflect the state of pulmonary endothelial cell function in clinical situations, considering that it has been demonstrated that MIBG may be useful as a marker of pulmonary endothelial cell function in the isolated rat lung.
对64例心肺疾病患者进行了123I-间碘苄胍（MIBG）心肌闪烁扫描。通过平面图像评估MIBG在胸部的分布，使用心脏与纵隔（H/M）以及单侧肺与纵隔（Lu/M）的计数比。大多数心脏病患者显示MIBG在肺部有明显摄取。无心力衰竭组的H/M比值为1.75±0.20，心力衰竭组为1.55±0.19。无心力衰竭组右肺和左肺的Lu/M比值分别为1.56±0.16和1.28±0.16。心力衰竭组则分别为1.45±0.16和1.19±0.15。但3例合并慢性肺气肿的患者和1例因皮肌炎导致间质性肺炎的患者显示肺部摄取明显降低。这些患者右肺和左肺的Lu/M比值分别为1.20、1.17；1.17、1.13；1.01、0.97和1.27、0.94。这些结果表明，考虑到在离体大鼠肺中已证明MIBG可作为肺内皮细胞功能的标志物，MIBG的肺部摄取可能反映临床情况下肺内皮细胞功能的状态。
