某些水杨酸盐和磺胺类药物对SPC - 703及甲苯磺丁脲与白蛋白结合的影响。
Influence of some salicylates and sulfonamides on binding by albumin of SPC-703 and tolbutamide.
作者信息
Wójcikowski C, Szlabowicz D
出版信息
Pol J Pharmacol Pharm. 1976;28(2):129-35.
Bovine serum albumin has two different binding sites for sulfonylurea. The sites at high affinity can bind up to 2 moles of a new hypoglycemic sulfonylurea SPC-703 (k1=6.8.10(3) M(-1)) or tolbutamide K1=19.3.10(3) M(-1)). The sites of lower affinity can bind 4 mole of SPC-703 (K2=1.6.10(3) M(-1)) or 8 moles of tolbutamide (k2=1.3.10(3) M(-1)). Binding of SPC-703 and tolbutamide was decreased mostly in the presence of sulfadimetoxine, but this sulfonamide increased the concentration of free tolbutamide more than that of SPC-703.
牛血清白蛋白对磺脲类药物有两个不同的结合位点。高亲和力位点可结合多达2摩尔的新型降糖磺脲类药物SPC - 703（k1 = 6.8×10³ M⁻¹）或甲苯磺丁脲（K1 = 19.3×10³ M⁻¹）。低亲和力位点可结合4摩尔的SPC - 703（K2 = 1.6×10³ M⁻¹）或8摩尔的甲苯磺丁脲（k2 = 1.3×10³ M⁻¹）。在磺胺二甲氧嘧啶存在的情况下，SPC - 703和甲苯磺丁脲的结合大多减少，但这种磺胺类药物使游离甲苯磺丁脲浓度的增加幅度大于SPC - 703。
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