三种具有不同转移能力的小鼠乳腺肿瘤细胞系的促聚集和促凝血特性。

Proaggregatory and procoagulant properties of three murine mammary gland tumor cell lines with different metastatic capabilities.

作者信息

Pasqualini M E, Ruiz Moreno L, Muñoz S E, Eynard A R

机构信息

Departamento de Histología, Embriología y Genética, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.

出版信息

Exp Toxicol Pathol. 1997 Dec;49(5):403-7. doi: 10.1016/s0940-2993(97)80127-3.

DOI:10.1016/s0940-2993(97)80127-3

PMID:9455689

Abstract

We have investigated the in vitro proaggregatory and procoagulant properties of three murine tumor cell lines having different metastatic potentials. The characterization was carried out with appropriate procoagulant inhibitors and plasma deficient in factors VII and X. The proaggregatory properties of M2, M3 and MM3 cell lines increased according to their metastatic potentials. Their procoagulant activity were dependent on factor X. The prothrombotic abilities exhibited by neoplastic cells (NC), acting synergistically, might play a role in cancer dissemination.

摘要

我们研究了三种具有不同转移潜能的小鼠肿瘤细胞系的体外促聚集和促凝血特性。使用适当的促凝血抑制剂和缺乏因子VII和X的血浆进行了表征。M2、M3和MM3细胞系的促聚集特性根据其转移潜能而增加。它们的促凝血活性依赖于因子X。肿瘤细胞（NC）协同发挥的促血栓形成能力可能在癌症扩散中起作用。