Huang Y H, Tsai S J, Huang H J, Sim C B
Institute and Department of Anatomy, National Yang-Ming University, Taipei, Taiwan, ROC.
Eur J Pharmacol. 1997 Nov 5;338(2):117-21. doi: 10.1016/s0014-2999(97)81938-3.
Repeated amphetamine administration can cause an augmentation of regional cerebral metabolic activity. This study analyzed the regional cerebral metabolic changes which occurred in rats after pretreatment with the selective dopamine D1 and D2 receptor agonists, (+/-)SKF 38393 ((+/-)-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine HCl) and quinpirole (trans-(-)-4aR-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrazolo(3, 4-g)quinoline), as measured by the 2-[14C]deoxyglucose method. The results showed selective metabolic augmentation in rats pretreated with SKF 38393 but not in those pretreated with quinpirole alone or with quinpirole in combination with SKF 38393. These findings demonstrated that dopamine D1 receptors may play a critical role in the development of metabolic augmentation after repeated stimulant administration.
反复给予苯丙胺可导致局部脑代谢活动增强。本研究采用2-[¹⁴C]脱氧葡萄糖法分析了用选择性多巴胺D1和D2受体激动剂（±）SKF 38393（（±）-2,3,4,5-四氢-7,8-二羟基-1-苯基-1H-3-苯并氮杂卓盐酸盐）和喹吡罗（反式（-）-4aR-4,4a,5,6,7,8,8a,9-八氢-5-丙基-1H-吡唑并[3,4-g]喹啉）预处理的大鼠发生的局部脑代谢变化。结果显示，用SKF 38393预处理的大鼠有选择性代谢增强，而单独用喹吡罗或喹吡罗与SKF 38393联合预处理的大鼠则没有。这些发现表明，多巴胺D1受体可能在反复给予兴奋剂后代谢增强的发展中起关键作用。
