Stromberg D, Fraser C D, Sorof J M, Drescher K, Feltes T F
Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Tex Heart Inst J. 1997;24(4):269-77.
Patients requiring cardiopulmonary bypass for congenital heart surgery commonly exhibit impaired renal function and extravascular fluid retention. These conditions contribute to early postoperative fluid overload, which may result in significant morbidity and mortality. We examined the safety and efficacy of peritoneal dialysis in removing extravascular fluid from critically ill postcardiotomy patients. A retrospective case review from July of 1995 through April of 1996 was conducted. All patients undergoing peritoneal dialysis achieved a net negative fluid balance. Average urine output increased from 2.1 cc/kg/hr to 3.9 cc/kg/hr (P < 0.01) during the pre-peritoneal dialysis to post-peritoneal dialysis period, and the mean number of inotropic agents decreased from 2.2 to 1.7 (P < 0.05). Controlled comparison revealed that the peritoneal dialysis cohort more rapidly achieved a negative weight-adjusted fluid balance throughout the early postoperative course. The peritoneal dialysis group's illness severity decreased more rapidly within the 24-hour period after initiation of peritoneal dialysis than did that of the control cohort over the same period of time. No difference in postoperative morbidity or mortality existed between the study groups. Complications from the catheter placement were minimal, and no patient experienced peritonitis or metabolic or hemodynamic instability during peritoneal dialysis catheter placement, usage, or removal. Peritoneal dialysis is a safe and effective form of renal replacement therapy, even among critically ill pediatric postcardiotomy patients. Early postsurgical institution of peritoneal dialysis may hasten early postoperative recovery. We speculate that intraoperative catheter placement reduces the complication rate associated with this treatment modality.
需要进行体外循环先天性心脏手术的患者通常存在肾功能受损和血管外液体积聚的情况。这些状况会导致术后早期液体超负荷,进而可能引发严重的发病率和死亡率。我们研究了腹膜透析在清除心脏手术后重症患者血管外液体方面的安全性和有效性。对1995年7月至1996年4月进行了回顾性病例分析。所有接受腹膜透析的患者均实现了净负液体平衡。在腹膜透析前至腹膜透析后的时间段内,平均尿量从2.1毫升/千克/小时增加至3.9毫升/千克/小时(P < 0.01),且平均血管活性药物使用数量从2.2降至1.7(P < 0.05)。对照比较显示,腹膜透析组在术后早期整个过程中更迅速地实现了体重调整后的负液体平衡。腹膜透析组在开始腹膜透析后的24小时内疾病严重程度的下降速度比同期对照组更快。研究组之间术后发病率或死亡率无差异。导管置入的并发症极少,在腹膜透析导管置入、使用或拔除过程中,没有患者发生腹膜炎或代谢或血流动力学不稳定情况。腹膜透析是一种安全有效的肾脏替代治疗方式,即使在心脏手术后的重症儿科患者中也是如此。术后早期进行腹膜透析可能会加速术后早期恢复。我们推测术中置入导管可降低与这种治疗方式相关的并发症发生率。