通过高效液相色谱-质谱联用技术确认夹竹桃中毒

Confirmation of oleander poisoning by HPLC/MS.

作者信息

Tracqui A, Kintz P, Branche F, Ludes B

机构信息

Institut de Médecine Légale, Faculte de Medecine, Strasbourg, France.

出版信息

Int J Legal Med. 1998;111(1):32-4. doi: 10.1007/s004140050107.

DOI:10.1007/s004140050107

PMID:9457536

Abstract

A non-fatal case of Nerium oleander (common oleander) self-poisoning in a 45-year-old female is presented. Initial symptoms were nausea and vomiting, abdominal pain, phosphenes, cardiovascular shock and sinus brady-cardia. Blood and urine were assayed for oleandrin, the major cardiac glycoside of N. oleander, using a highly specific HPLC/MS procedure. The blood concentration of oleandrin at admission was 1.1 ng/ml. This is the first report of an oleander intoxication ascertained by the mass spectrometric identification of oleandrin in blood. HPLC/MS appears to be the method of choice for the forensic-toxicological investigation of poisonings by cardiac glycosides.

摘要

本文报告了一例45岁女性夹竹桃（欧洲夹竹桃）自服中毒未致死的病例。初始症状为恶心、呕吐、腹痛、光幻视、心血管休克和窦性心动过缓。采用高特异性的高效液相色谱/质谱法检测血液和尿液中的夹竹桃苷，夹竹桃苷是夹竹桃的主要强心苷。入院时血液中夹竹桃苷浓度为1.1 ng/ml。这是首次通过质谱鉴定血液中的夹竹桃苷来确定夹竹桃中毒的报告。高效液相色谱/质谱法似乎是强心苷中毒法医毒理学调查的首选方法。