纤维肌痛患者生长激素分泌不足——10例患者及10例对照的初步报告
Low growth hormone secretion in patients with fibromyalgia--a preliminary report on 10 patients and 10 controls.
作者信息
Bagge E, Bengtsson B A, Carlsson L, Carlsson J
机构信息
Department of Rheumatology, the Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden.
出版信息
J Rheumatol. 1998 Jan;25(1):145-8.
OBJECTIVE
To evaluate the secretion of growth hormone in patients with fibromyalgia (FM).
METHODS
Serum concentrations of growth hormone (24 h profiles), insulin-like growth factor I (IGF), and IGF binding protein-3 were determined in 10 women with FM and in 10 healthy controls. Quality of sleep was assessed by means of a visual analog scale.
RESULTS
Sleep was significantly more disturbed in the patients than in controls. A significantly lower secretion of growth hormone was found in the patients in comparison with healthy controls.
CONCLUSION
These results suggest that growth hormone secretion is decreased in patients with FM. Substitution therapy with low doses of growth hormone may be worth evaluating in the treatment of FM.
目的
评估纤维肌痛（FM）患者的生长激素分泌情况。
方法
测定10名FM女性患者和10名健康对照者的血清生长激素浓度（24小时曲线）、胰岛素样生长因子I（IGF）以及IGF结合蛋白-3。通过视觉模拟量表评估睡眠质量。
结果
患者的睡眠障碍明显比对照者更严重。与健康对照者相比，患者的生长激素分泌显著降低。
结论
这些结果表明FM患者的生长激素分泌减少。低剂量生长激素替代疗法在FM治疗中可能值得评估。
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