Jacobson J M
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Mt Sinai J Med. 1998 Jan;65(1):22-6.
Neutralizing antibodies are a component of the immune response to acute human immunodeficiency virus infection. Levels of these antibodies diminish with the clinical progression of HIV disease. The results of several clinical studies of humoral passive immunization for advanced HIV disease suggest no clear antiviral or immune-enhancing effect. However, some studies reported delay in the occurrence of opportunistic infections and prolongation of life. Further studies are needed to more specifically define the role of humoral immune response in preventing and controlling HIV infection, and the potential for augmentation of these responses in prophylaxis and treatment.
中和抗体是人体对急性人类免疫缺陷病毒感染免疫反应的一个组成部分。随着HIV疾病的临床进展，这些抗体的水平会下降。针对晚期HIV疾病进行体液被动免疫的几项临床研究结果表明，没有明显的抗病毒或免疫增强作用。然而，一些研究报告称机会性感染的发生有所延迟，生存期有所延长。需要进一步研究以更明确地界定体液免疫反应在预防和控制HIV感染中的作用，以及在预防和治疗中增强这些反应的潜力。
