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Association of beta 3-adrenoceptor polymorphism with obesity and diabetes: current status.

作者信息

Strosberg A D

机构信息

Laboratoire d'Immuno-Pharmacologie Moléculaire, CNRS UPR 0415, Paris, France.

出版信息

Trends Pharmacol Sci. 1997 Dec;18(12):449-54. doi: 10.1016/s0165-6147(97)01133-4.

DOI:10.1016/s0165-6147(97)01133-4
PMID:9458691
Abstract
摘要

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Association of beta 3-adrenoceptor polymorphism with obesity and diabetes: current status.
Trends Pharmacol Sci. 1997 Dec;18(12):449-54. doi: 10.1016/s0165-6147(97)01133-4.
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A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride.β3-肾上腺素能受体的一种突变与内脏肥胖相关，但会降低血清甘油三酯水平。
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A mutation in the beta 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects.β3 - 肾上腺素能受体基因突变与日本人群的肥胖和高胰岛素血症相关。
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The beta 3-adrenergic receptor gene Trp64Arg mutation is overrepresented in obese women. Effects on weight, BMI, abdominal fat, blood pressure, and reproductive history in an elderly Australian population.β3肾上腺素能受体基因Trp64Arg突变在肥胖女性中过度存在。对澳大利亚老年人群体重、体重指数、腹部脂肪、血压及生殖史的影响。
Diabetes. 1996 Oct;45(10):1358-63. doi: 10.2337/diab.45.10.1358.

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The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis.β肾上腺素能受体 Trp64Arg 多态性与胰岛素抵抗的关联：荟萃分析。
Front Endocrinol (Lausanne). 2021 Aug 26;12:708139. doi: 10.3389/fendo.2021.708139. eCollection 2021.
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Insights into the binding modes of human β₃-adrenergic receptor agonists with ligand-based and receptor-based methods.基于配体和受体方法的人β₃-肾上腺素能受体激动剂结合模式的研究。
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Norepinephrine directly activates adult hippocampal precursors via beta3-adrenergic receptors.
去甲肾上腺素通过β3-肾上腺素能受体直接激活成年海马前体细胞。
J Neurosci. 2010 Feb 17;30(7):2795-806. doi: 10.1523/JNEUROSCI.3780-09.2010.
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Characterization of beta3-adrenergic receptor: determination of pharmacophore and 3D QSAR model for beta3 adrenergic receptor agonism.β3肾上腺素能受体的表征：β3肾上腺素能受体激动作用的药效团确定及三维定量构效关系模型
J Comput Aided Mol Des. 2005 Feb;19(2):93-110. doi: 10.1007/s10822-005-1558-7.
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Beta-adrenoceptor polymorphisms.β-肾上腺素能受体多态性
Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):1-22. doi: 10.1007/s00210-003-0824-2. Epub 2003 Nov 28.