2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
作者信息
Micheli F, Cugola A, Donati D, Missio A, Pecunioso A, Reggiani A, Tarzia G
机构信息
GlaxoWellcome S.p.A., Medicines Research Center, Verona, Italy.
出版信息
Bioorg Med Chem. 1997 Dec;5(12):2129-32. doi: 10.1016/s0968-0896(97)00156-9.
PMID:9459010
Abstract
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo.
摘要
Zotero 插件