Bliven M L, Eskra J D, Otterness I G
Department of Cancer, Immunology and Infectious Diseases, Pfizer Inc., Groton, CT 06340, USA.
Inflamm Res. 1997 Dec;46(12):491-5. doi: 10.1007/s000110050231.
The limitation of activity and its modification by therapy in an experimental arthritis was studied.
Female hamsters in groups of six per treatment were used.
An acute arthritis was induced by intraarticular injection of 0.1 microgram lipopolysaccharide (LPS) in hamsters with free access to running wheels. Tenidap at 100 mg%, and piroxicam and indomethacin at 30 mg% were administered in the hamster's normal diet.
Activity was monitored and analysed by computer. Plasma blood levels of drugs were determined by high pressure liquid chromatographic (HPLC) analysis.
Hamsters normally run 10-15 km/day. That distance was reduced to less than 2 km/day after arthritis induction. Speed of movement, essentially the equivalent of walking time, was reduced 40% by the arthritis. However, the time spent in movement (activity time) was more severely affected by arthritic disease. Therapy gave a modest 1.3-fold increase in speed of movement, but a highly significant 2-fold increase in activity time.
The effects of arthritis on activity in this animal model suggest that time spent in movement (activity time) should be considered as an outcome measure in clinical studies. These observations may also help explain why the modest disease improvements obtained with cyclooxygenase inhibition are valued. From a patient perspective, a doubling of activity time is a highly significant improvement in quality-of-life.
研究实验性关节炎中活动受限情况及其通过治疗的改善情况。
采用每组六只接受每种治疗的雌性仓鼠。
对可自由使用跑步轮的仓鼠进行关节腔内注射0.1微克脂多糖（LPS）诱导急性关节炎。在仓鼠的正常饮食中给予100毫克%的替硝唑、30毫克%的吡罗昔康和吲哚美辛。
通过计算机监测和分析活动情况。采用高压液相色谱（HPLC）分析法测定血浆中药物水平。
仓鼠正常情况下每天跑10 - 15千米。关节炎诱导后，该距离降至每天不足2千米。运动速度，基本上等同于行走时间，因关节炎降低了40%。然而，运动所花费的时间（活动时间）受关节炎疾病的影响更为严重。治疗使运动速度适度提高了1.3倍，但使活动时间显著增加了2倍。
在该动物模型中关节炎对活动的影响表明，运动所花费的时间（活动时间）应被视为临床研究中的一项结果指标。这些观察结果或许也有助于解释为何抑制环氧化酶所带来的适度疾病改善受到重视。从患者角度来看，活动时间翻倍是生活质量的显著改善。
