Duijkers I J, Willemsen W N, Hollanders H M, Hamilton C J, Thomas C M, Vemer H M
Department of Obstetrics and Gynecology, University Hospital Nijmegen St. Radboud, The Netherlands.
Int J Fertil Womens Med. 1997 Nov-Dec;42(6):426-30.
The aim of the present randomized study was to investigate whether ovarian stimulation treatment with gonadotropin preparations containing different amounts of LH activity resulted in variations of steroidal composition of follicular fluid. A different endocrine milieu within the follicle might influence oocyte quality.
Antral fluid from mature follicles was collected in in vitro fertilization cycles and concentrations of testosterone, androstenedione, estrone, estradiol, progesterone, FSH, and LH were determined. A comparison was made between treatment with a purified FSH preparation (nine patients, 35 follicular fluid samples) and a FSH-dominant human menopausal gonadotropin (hMG) preparation (nine patients, 34 samples).
No differences in any of the hormone levels could be detected between the two groups.
Treatment with gonadotropin preparations containing different FSH/LH ratios did not result in different androgen, estrogen and progesterone levels in follicular fluid.
本随机研究旨在调查使用含有不同量促黄体生成素（LH）活性的促性腺激素制剂进行卵巢刺激治疗是否会导致卵泡液甾体成分的变化。卵泡内不同的内分泌环境可能会影响卵母细胞质量。
在体外受精周期中收集成熟卵泡的卵泡液，测定睾酮、雄烯二酮、雌酮、雌二醇、孕酮、促卵泡生成素（FSH）和促黄体生成素（LH）的浓度。对使用纯化FSH制剂治疗的患者（9例，35份卵泡液样本）和以FSH为主的人绝经期促性腺激素（hMG）制剂治疗的患者（9例，34份样本）进行比较。
两组之间未检测到任何激素水平的差异。
使用含有不同FSH/LH比值的促性腺激素制剂治疗不会导致卵泡液中雄激素、雌激素和孕酮水平的差异。
