Nitschelm D, Van der Horst C J
Tijdschr Diergeneeskd. 1976 Jul 15;101(14):796-804.
It has been shown that stimulation of the uterus of mares by the daily taking of biopsies can result in the occurrence of oestrous symptoms. This is accompanied by some follicular growth and a progesterone content in the blood often higher than 1 ng/ml. The following observations suggest that this progesterone originates in the uterus and not in the ovaries: (1) no active corpora lutea appeared to be present in the ovaries after ovariectomy, (2) ovariectomized mares showed the same oestrous symptoms in similar experiments and even mating took place, (3) in the uterine biopsies the concentration of the compound referred to as "5.4", which is assumed to be easily convertible into progesterone, had already increased considerably in the second biopsy, (4) administration of stilboestrol reduced the rise of the progesterone level in the uterine biopsies as well as in the blood. The absence of oestradiol-17 beta in the ovarian follicles and the fact that ovariectomized mares also come into heat suggest that oestrogens cannot be held responsible for the oestrous symptoms in these mares. Our experiments demonstrate that the uterus can be involved in sexual behaviour and the formation of steroids.
已表明，通过每天进行活检刺激母马子宫会导致出现发情症状。这伴随着一些卵泡生长，且血液中的孕酮含量通常高于1纳克/毫升。以下观察结果表明，这种孕酮源自子宫而非卵巢：（1）卵巢切除术后，卵巢中似乎不存在活跃的黄体；（2）在类似实验中，卵巢切除的母马表现出相同的发情症状，甚至还发生了交配；（3）在子宫活检中，被称为“5.4”的化合物（假定易于转化为孕酮）的浓度在第二次活检时就已大幅增加；（4）己烯雌酚的给药降低了子宫活检组织以及血液中孕酮水平的升高。卵巢卵泡中缺乏雌二醇-17β以及卵巢切除的母马也会发情这一事实表明，雌激素并非这些母马发情症状的原因。我们的实验证明，子宫可参与性行为和类固醇的形成。
