哺乳动物人工染色体——用于体细胞基因治疗的载体。

Mammalian artificial chromosomes--vectors for somatic gene therapy.

作者信息

Ascenzioni F, Donini P, Lipps H J

机构信息

Instituto Pasteur, Fondazione Cenci Bolognetti, Dipartimento di Biologia cellulare e dello Sviluppo, University of Rome, Italy.

出版信息

Cancer Lett. 1997 Oct 14;118(2):135-42. doi: 10.1016/s0304-3835(97)00323-6.

DOI:10.1016/s0304-3835(97)00323-6

PMID:9459203

Abstract

Mammalian artificial chromosomes might prove to be useful vectors for somatic gene therapy. The functional elements of such an artificial chromosome are telomeres, a centromere and a replication origin. Recent progress in the characterization of these functional elements of the eukaryotic chromosome will be described. Attempts to construct artificial chromosomes for mammalian cells and their use for somatic gene therapy are discussed.

摘要

哺乳动物人工染色体可能被证明是用于体细胞基因治疗的有用载体。这种人工染色体的功能元件是端粒、着丝粒和复制起点。将描述真核染色体这些功能元件表征方面的最新进展。还将讨论构建哺乳动物细胞人工染色体的尝试及其在体细胞基因治疗中的应用。