泮库溴铵或筒箭毒碱对硫喷妥钠-氧化亚氮-氟烷麻醉期间循环反应的影响。
Influence of pancuronium or d-tubocurarine on circulatory responses during thiamylal-N2O-halothane anesthesia.
作者信息
Stoelting R K
出版信息
Anesth Analg. 1976 Jul-Aug;55(4):485-8.
Circulatory responses after thiamylal (4 mg/kg) and pancuronium (0.08 mg/kg, 20 patients) or d-tubocurarine (dTc, 0.5 mg/kg, 20 patients) followed by tracheal intubation and nitrous oxide-halothane administration were measured. Three minutes after thiamylal, the mean arterial pressure (MAP) and cardiac index (CI) decreased significantly only in patients receiving dTc. Heart rate (HR) was increased 12 bpm in both groups. The magnitude of reduction in MAP and CI was similar and the HR was not greatly different between groups after 5 minutes of N2O-halothane administration. MAP and CI were better maintained following thiamylal in patients receiving pancuronium as compared with dTc. However, circulatory responses during early anesthetic maintenance were not influenced by the choice of neuromuscular blocker.
对20例患者静脉注射硫喷妥钠（4mg/kg）和泮库溴铵（0.08mg/kg）或筒箭毒碱（dTc，0.5mg/kg），随后进行气管插管并给予氧化亚氮-氟烷，测量其循环反应。注射硫喷妥钠3分钟后，仅接受dTc的患者平均动脉压（MAP）和心脏指数（CI）显著下降。两组患者心率（HR）均增加12次/分钟。给予氧化亚氮-氟烷5分钟后，两组患者MAP和CI的降低幅度相似，HR差异不大。与接受dTc的患者相比，接受泮库溴铵的患者在注射硫喷妥钠后MAP和CI维持得更好。然而，麻醉维持早期的循环反应不受神经肌肉阻滞剂选择的影响。
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