Binetti G, Cappa S F, Magni E, Padovani A, Bianchetti A, Trabucchi M
S. Cuore-Fatebenefratelli Hospital, Brescia, Italy.
Neuropsychology. 1998 Jan;12(1):29-33. doi: 10.1037//0894-4105.12.1.29.
A battery of visuospatial perception tests was administered to 27 mild probable Alzheimer's disease (AD) patients; 21 were reassessed after 8 months. At the first evaluation, AD patients were impaired only in an object-naming task. After 8 months, the performance in the subtests of object perception was unchanged, while there was a significant decline in the total score of the items tapping space perception. A significant worsening was also observed in the Rey's figure copy score and was correlated with the decrease in the spatial perception score. This study confirms that an impairment in visual perceptual tests requiring access to semantic and lexical knowledge is present in the earliest phase of AD, whereas visuospatial and constructional impairments became evident only later. This pattern of progression may represent the clinical correlate of increasing pathological involvement of posterior associative cortex.
对27名轻度可能患有阿尔茨海默病（AD）的患者进行了一系列视觉空间感知测试；其中21名患者在8个月后进行了重新评估。在首次评估时，AD患者仅在物体命名任务中受损。8个月后，物体感知子测试的表现没有变化，而涉及空间感知的项目总分显著下降。在雷伊图形复制分数中也观察到显著恶化，且与空间感知分数的下降相关。这项研究证实，在AD的最早阶段就存在需要语义和词汇知识的视觉感知测试受损，而视觉空间和构建能力受损仅在后来才变得明显。这种进展模式可能代表了后联合皮层病理累及增加的临床相关性。
