非那雄胺与氟他胺治疗多毛症

[Finasteride and flutamide in the treatment of hirsutism].

作者信息

Falsetti L, De Fusco D, Rosina B

机构信息

Dipartimento di Ginecologia Endocrinologica, Università degli Studi, Brescia.

出版信息

Minerva Ginecol. 1997 Oct;49(10):463-8.

PMID:9463180

Abstract

BACKGROUND

The aim of this work was to evaluate the efficacy of two new antiandrogen drugs, finasteride and flutamide, in 80 hirsute patients: 44 with Polycystic Ovary Syndrome (PCOS) and 36 with Idiopathic Hirsutism (IH).

METHODS

The study was conducted in a randomized way and randomization was carried out according to hospitalization. Before and after the treatment, all of the patients underwent hematochemical tests, hormone assays and assessment of hirsutism with the Ferriman Gallway score (F.G. score) and with measurement of the hair diameter in four different body areas. Finasteride was administered per os to 40 women at the dose of 5 mg/die; flutamide per os to 40 women at the dose of 250 mg twice daily. Both drugs were employed for 6 consecutive months.

RESULTS

Both finasteride and flutamide significantly reduced the F.G. score and hair diameter.

CONCLUSIONS

Abdominal hairs were more sensitive to the therapy.

摘要

背景

本研究旨在评估两种新型抗雄激素药物非那雄胺和氟他胺对80例多毛症患者的疗效，其中44例为多囊卵巢综合征（PCOS）患者，36例为特发性多毛症（IH）患者。

方法

本研究采用随机方式进行，随机分组依据住院情况。治疗前后，所有患者均接受血液生化检查、激素测定，并使用费里曼-盖尔韦评分（F.G.评分）以及测量四个不同身体部位的毛发直径来评估多毛症情况。40名女性口服非那雄胺，剂量为5毫克/天；40名女性口服氟他胺，剂量为250毫克，每日两次。两种药物均连续使用6个月。