Hassler O
Arch Pathol Lab Med. 1976 Feb;100(2):97-9.
Thrombosis was experimentally induced in one common carotid artery in 40 rats. One hour to 180 days afterward, the cell renewal in the arterial wall was studied by tritiated thymidine autoradiography. An increased number of labeled cells were observed, especially in the early developmental phase of the thrombosis and mainly in the tunica media. These findings seem to accord best with the hypothesis that the thrombi are mainly organized by smooth muscle cells from the tunica media, which are partly dedifferentiated toward fibroblast-like cells.
在40只大鼠的一条颈总动脉中通过实验诱导形成血栓。在之后1小时至180天期间，采用氚标记胸腺嘧啶核苷放射自显影术研究动脉壁中的细胞更新情况。观察到标记细胞数量增加，尤其在血栓形成的早期发育阶段，且主要位于中膜。这些发现似乎最符合以下假说：血栓主要由来自中膜的平滑肌细胞机化，这些平滑肌细胞部分去分化为成纤维细胞样细胞。
