Murphy V J, Yang Z, Rorison K A, Baldwin G S
Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.
Cancer Lett. 1998 Jan 9;122(1-2):25-30. doi: 10.1016/s0304-3835(97)00361-3.
Non-steroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. We now report that the potent cyclooxygenase-1 inhibitor indomethacin had no effect on the growth of human colorectal carcinoma cell lines in vitro at concentrations up to 30 microM. The selective cyclooxygenase-2 inhibitors L-745337 and NS-398 reduced cyclooxygenase activity, but had no effect on cell growth at concentrations as high as 100 microM. Our results provide direct evidence that inhibition of cyclooxygenase activity does not necessarily inhibit the growth of colorectal carcinoma cell lines and imply that the growth-inhibitory effects of NSAIDs in vitro are not mediated by inhibition of cyclooxygenases.
非甾体抗炎药（NSAIDs）可降低结直肠癌的发病率。我们现在报告，强效环氧化酶-1抑制剂吲哚美辛在浓度高达30微摩尔时，对人结肠癌细胞系的体外生长没有影响。选择性环氧化酶-2抑制剂L-745337和NS-398可降低环氧化酶活性，但在浓度高达100微摩尔时对细胞生长没有影响。我们的结果提供了直接证据，表明抑制环氧化酶活性不一定会抑制结肠癌细胞系的生长，这意味着NSAIDs在体外的生长抑制作用不是由环氧化酶的抑制介导的。
