Bianco A T, Smilen S W, Davis Y, Lopez S, Lapinski R, Lockwood C J
Department of Obstetrics and Gynecology, The Mount Sinai Medical Center, New York, New York, USA.
Obstet Gynecol. 1998 Jan;91(1):97-102. doi: 10.1016/s0029-7844(97)00578-4.
To compare pregnancy outcomes between morbidly obese and nonobese women and to determine the effect of gestational weight gain on pregnancy outcome in morbidly obese women.
A retrospective cohort study was conducted comparing 613 morbidly obese and 11,313 nonobese women who were delivered of a singleton live birth. Morbid obesity was defined as a body mass index greater than 35. The incidence of selected perinatal and neonatal outcomes was assessed for the two groups. Multiple logistic regression analysis was used to evaluate the association between morbid obesity and various measures of outcome while controlling for potential confounders. A subanalysis of the morbidly obese patients was performed to assess the effect of gestational weight gain on pregnancy outcome.
Morbidly obese patients were more likely to experience pregnancy complications including diabetes, hypertension, preeclampsia, and arrest-of-labor disorders; however, these were not affected by gestational weight gain. Morbidly obese patients were more likely to experience fetal distress and meconium and to undergo cesarean delivery than their nonobese counterparts (P < .05). Weight gains of more than 25 lb were associated strongly with birth of a large for gestational age (LGA) neonate (P < .01); however, poor weight gain did not appear to increase the risk of delivery of a low birth weight neonate.
Gestational weight gain was not associated with adverse perinatal outcome, but it did influence neonatal outcome. To reduce the risk of delivery of an LGA newborn, the optimal gestational weight gain for morbidly obese women should not exceed 25 lb.
比较极度肥胖和非肥胖女性的妊娠结局,并确定孕期体重增加对极度肥胖女性妊娠结局的影响。
进行一项回顾性队列研究,比较613例极度肥胖和11313例非肥胖的单胎活产女性。极度肥胖定义为体重指数大于35。评估两组选定的围产期和新生儿结局的发生率。采用多因素logistic回归分析评估极度肥胖与各种结局指标之间的关联,同时控制潜在的混杂因素。对极度肥胖患者进行亚分析,以评估孕期体重增加对妊娠结局的影响。
极度肥胖患者更易发生妊娠并发症,包括糖尿病、高血压、先兆子痫和产程停滞障碍;然而,这些并发症不受孕期体重增加的影响。与非肥胖患者相比,极度肥胖患者更易出现胎儿窘迫和胎粪污染,并更易接受剖宫产(P <.05)。体重增加超过25磅与大于胎龄(LGA)新生儿的出生密切相关(P <.01);然而,体重增加不佳似乎并未增加低出生体重新生儿的分娩风险。
孕期体重增加与不良围产期结局无关,但确实会影响新生儿结局。为降低LGA新生儿的分娩风险,极度肥胖女性的最佳孕期体重增加不应超过25磅。