Bal Mehmet, Şahin Ersoy Gülçin, Demirtaş Ömer, Kurt Sefa, Taşyurt Abdullah
Tepecik Education and Research Hospital, Department of Obstetrics and Gynecology, İzmir, Turkey.
Turk J Obstet Gynecol. 2016 Mar;13(1):23-26. doi: 10.4274/tjod.10170. Epub 2016 Mar 10.
We aimed to investigate the effect of vitamin D deficiency as a risk factor for the development of gestational diabetes mellitus (GDM) among pregnant women without known risk factors.
The study was conducted on pregnant women who had been under regular follow-up and had low risk for GDM development. The patients were divided into two groups according to the presence of GDM; GDM and no GDM (control) group. Body mass index (BMI), sociodemographic data including level of education and nutritional habits were recorded. Serum 25 (OH) vitamin D levels, hemoglobin, hematocrit, and mean corpuscular volume (MCV) values were measured. An oral glucose tolerance test was performed, between 24 and 28 weeks of pregnancy.
GDM ratio was calculated as 4.6%. The false positive rate of 50 g oral glucose load screening test was found to be 16.5%. The BMI levels of women diagnosed as having GDM and those with no GDM group at the beginningof the pregnancy period were calculated as 24.3±2.6 and 22.8±1.6 kg/m2 respectively, exhibiting a statistically significant difference between the two groups (p=0.001). Hemoglobin, hematocrit, and MCV values did not show a statistically significant difference between the two groups (p>0.05). The levels of 25 (OH) vitamin D of the study groups were found comparable in both groups (p=0.13).
Plasma levels of vitamin D may not be a contributing factor for the development of GDM in women with a low risk for GDM.
我们旨在研究维生素D缺乏作为无已知危险因素的孕妇发生妊娠期糖尿病（GDM）的风险因素的影响。
本研究针对接受定期随访且发生GDM风险较低的孕妇进行。根据是否患有GDM将患者分为两组；GDM组和无GDM组（对照组）。记录体重指数（BMI）、社会人口统计学数据，包括教育程度和营养习惯。测量血清25（OH）维生素D水平、血红蛋白、血细胞比容和平均红细胞体积（MCV）值。在妊娠24至28周之间进行口服葡萄糖耐量试验。
GDM发生率计算为4.6%。发现50 g口服葡萄糖负荷筛查试验的假阳性率为16.5%。妊娠初期被诊断为患有GDM的女性和无GDM组女性的BMI水平分别计算为24.3±2.6和22.8±1.6 kg/m²，两组之间存在统计学显著差异（p = 0.001）。两组之间的血红蛋白、血细胞比容和MCV值未显示出统计学显著差异（p>0.05）。研究组的25（OH）维生素D水平在两组中相当（p = 0.13）。
对于发生GDM风险较低的女性，血浆维生素D水平可能不是GDM发生的促成因素。
