Galyean M L, Eng K S
West Texas A&M University, Canyon 79016-0001, USA.
J Anim Sci. 1998 Jan;76(1):323-7. doi: 10.2527/1998.761323x.
Updated research findings with acidosis, feedlot bloat, liver abscesses, and sudden death syndromes were presented at the Bud Britton Memorial Symposium on Metabolic Disorders of Feedlot Cattle. Possible industry applications include the need to establish guidelines for use of clostridial vaccines in feedlot cattle, further assessment of the relationship between acidosis and polioencephalomalacia, examination of the effects of various ionophores on the incidence of metabolic disorders, and evaluation of the effects of feed bunk management and limit- and restricted-feeding programs on the incidence of metabolic disorders. A multidisciplinary approach among researchers, consulting nutritionists and veterinarians, and feedlot managers will be required for effective progress in research and in the application of research findings. Areas suggested for further research include 1) assessment of feed consumption patterns and social behavior of cattle in large-pen, feedlot settings; 2) evaluation of the relationship between feed intake management systems (feed bunk management programs, limit- and programmed-feeding) and the incidence of metabolic disorders, including delineation of the role of variability in feed intake in the etiology of such disorders; 3) efforts to improve antemortem and postmortem diagnosis, and to establish standardized regional or national epidemiological databases for various metabolic disorders; 4) ascertaining the accuracy of diagnosis of metabolic disorders and determining the relationship of previous health history of animals to the incidence of metabolic disorders; 5) further defining ruminal and intestinal microbiology as it relates to metabolic disorders and deeper evaluation of metabolic changes that occur with such disorders; 6) continued appraisal of the effects of grain processing and specific feed ingredients and nutrients on metabolic disorders, and development of new feed additives to control or prevent these disorders; and 7) application of biotechnology to develop grain varieties with altered nutrient degradation profiles that decrease the propensity for disastrous acid loads in the rumen, feed-grade enzymes and probiotics that modify nutrient digestion or microbial profiles in the rumen and intestine, and specific strains of ruminal bacteria and protozoa that alter ruminal and metabolic conditions that may precipitate metabolic disorders.
在布德·布里顿肉牛代谢紊乱纪念研讨会上展示了关于酸中毒、育肥牛瘤胃胀、肝脓肿和猝死综合征的最新研究成果。该行业可能的应用包括需要制定育肥牛使用梭菌疫苗的指南,进一步评估酸中毒与脑灰质软化之间的关系,研究各种离子载体对代谢紊乱发病率的影响,以及评估饲槽管理和限量及限饲计划对代谢紊乱发病率的影响。研究人员、咨询营养学家和兽医以及育肥牛场管理人员之间需要采取多学科方法,才能在研究以及研究成果应用方面取得有效进展。建议进一步开展研究的领域包括:1)评估大围栏育肥牛场环境中牛的采食模式和社会行为;2)评估采食管理系统(饲槽管理计划、限量和程序化饲喂)与代谢紊乱发病率之间的关系,包括确定采食变化在这些疾病病因中的作用;3)努力改进生前和死后诊断,并建立各种代谢紊乱的标准化区域或国家流行病学数据库;4)确定代谢紊乱诊断的准确性,并确定动物既往健康史与代谢紊乱发病率之间的关系;5)进一步明确瘤胃和肠道微生物学与代谢紊乱的关系,并更深入地评估此类疾病发生时的代谢变化;6)持续评估谷物加工以及特定饲料成分和营养素对代谢紊乱的影响,并开发新的饲料添加剂来控制或预防这些疾病;7)应用生物技术培育具有改变的养分降解特性的谷物品种,以减少瘤胃酸负荷灾难的倾向,开发改变瘤胃和肠道养分消化或微生物特性的饲料级酶和益生菌,以及改变可能引发代谢紊乱的瘤胃和代谢条件的特定瘤胃细菌和原生动物菌株。